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By Abraham Fisher, Israel Hanin, Werner Poewe, Manfred Windisch

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Read or Download Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases) PDF

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Additional info for Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases)

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05). 05). Conclusions: We conclude that less coordinated and less explosive muscle force contributes to the change of FEF75%, and suggest parameters of PFT may be used as indicators of severity of IPD. Therefore PFT may be used in IPD for preventing pulmonary complications. Also, PFT may be used as indicators of severity of IPD. M. K. Raha , L. Ebenezer , S. Wilson 2 1 Department of Integrated Medicine, University Hospital of 2 Wales, Cardiff, Wales, Department of Integrated Medicine, Princess of Wales Hospital, Bridgend, Wales, UK Introduction: Neuropsychiatric, perceptual and cognitive deficits are increasingly recognized as non-motor manifestations of Parkinson's disease (PD).

While we observed that LRP6 is normally expressed in the adult human hippocampus, functional assays revealed that LRP6 alleles display differential activity on Wnt signaling. Conclusions: Our study unveils a novel genetic relationship between LRP6 and APOE and supports the hypothesis that altered Wnt signaling may be central in the onset of AD. Funding: RTM and GVD: HHMI and TLL Temple Award from the Alzheimer’s Association; FW-V, AJM and JH: NIA/NIH Intermural Program, USA; AP: Swiss National Science Foundation, Helmut Horten Stiftung, and EU APOPIS program.

Two different subtypes of Gprotein coupled receptors, MT1 and MT2, transmit some of melatonin’s effects in mammals. We have studied melatonin receptor alterations in different brain areas of AD patients using immunohistochemistry. Pyramidal neurons express both receptors in the human hippocampus. Whereas MT1 was decreased, the expression of MT2 was increased in AD hippocampus. Ganglion, amacrine, and photoreceptor cell of the retina expressed MT1 and MT2. The expression of both receptor was decreased in AD retina.

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